GENERIC NAME: Fexofenadine

Allegra (fexofenadine) is an antihistamine that reduces the effects of natural chemical histamine in the body.

Histamine can produce symptoms of sneezing Women's Montravius Adams Jersey , itching, watery eyes, and runny nose. It is also used to treat skin itching and hives caused by a condition called chronic idiopathic urticarial in adults and children. Allegra may also be used for purposes not listed in this medication guide.

Mechanism of Action

Allegra (fexofenadine hydrochloride), the major active metabolite of terfenadine, is an antihistamine with selective H1-receptor antagonist activity. Both enantiomers of Allegra (fexofenadine hydrochloride) displayed approximately equipotent antihistaminic effects. Allegra (fexofenadine hydrochloride) inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats. The clinical significance of these findings is unknown. In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed. Moreover, no sedative or other central nervous system effects were observed. Radiolabeled tissue distribution studies in rats indicated that fexofenadine does not cross the blood-brain barrier.

Side effect:

Get emergency medical help if you have any of these signs of an allergic reaction to Allegra: hives, difficulty breathing, swelling of your face, lips, tongue, or throat. Stop taking Allegra and call your doctor if you have fever, chills, body aches, cough, or other flu symptoms.

Less serious Allegra side effects may include:

nausea, diarrhea, upset stomach

menstrual cramps

drowsiness, tired feeling

headache

Muscle or back pain.

DOSING:

For seasonal allergies and urticaria the recommended dose for adults and children 12 years of age or older is 60 mg twice daily or 180 mg once daily. Children 2-11 years of age should be given 30 mg twice daily for seasonal allergies or urticarial.

Precautions:

Before taking fexofenadine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

DRUG INTERACTIONS:

Aluminum containing antacids (for example, Maalox) reduced the absorption of fexofenadine when administered 15 minutes apart. Therefore, aluminum containing antacids and fexofenadine should not be administered together. Fruit juices (apple, orange, and grapefruit) may reduce the absorption of fexofenadine. Fexofenadine should only be administered with water.

STORAGE:

Tablets and suspension should be stored at room temperature between 20-25 C (68-77 F).

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